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KMID : 0360220190600100915
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Journal of the Korean Ophthalmological Society
2019 Volume.60 No. 10 p.915 ~ p.921
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Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis
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Kim Chang-Hwan
Seong San
Kim Jong-Ku
Choi Jae-Ho
Choe Chul-Myong
Choi Tae-Hoon
Kim Se-Kyung
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Abstract
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Purpose: To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK).
Methods: This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK. The patients in the 3% diquafosol tetrasodium (DQ) group (37 patients, 74 eyes) were instructed to apply one drop of DQ, six times daily post-op, while the patients in the 0.3% sodium hyaluronate (HA) group (38 patients, 76 eyes) were instructed to apply one drop of HA, six times daily post-op. A Schirmer test, tear film break-up time (BUT), corneal and conjunctival fluorescein staining score (FLSS), and ocular surface disease index (OSDI) were evaluated pre-op and at 1, 4, and 12 weeks post-op while the tear osmolarity was evaluated pre-op and at 4 and 12 weeks post-op.
Results: There was no significant difference between the two groups regarding Schirmer test results or tear osmolarity and conjunctival FLSS. The BUT was significantly higher in the DQ group at 1 week and 12 weeks post-op. The corneal FLSS was significantly lower in the DQ group at 1 week, 4 weeks and 12 weeks post-op. The OSDI was significantly lower in the DQ group at 1 week post-op.
Conclusions: Use of 3% diquafosol tetrasodium after surgery improved ocular dryness and increased the tear film stability.
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KEYWORD
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Diquafosol, Dry eyes, laser-assisted in-situ keratomileusis, Tear film stability
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